Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments

[Image: see text] The stabilization of protein–protein interactions (PPIs) has emerged as a promising strategy in chemical biology and drug discovery. The identification of suitable starting points for stabilizing native PPIs and their subsequent elaboration into selective and potent molecular glues...

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Detalles Bibliográficos
Autores principales: Konstantinidou, Markella, Visser, Emira J., Vandenboorn, Edmee, Chen, Sheng, Jaishankar, Priyadarshini, Overmans, Maurits, Dutta, Shubhankar, Neitz, R. Jeffrey, Renslo, Adam R., Ottmann, Christian, Brunsveld, Luc, Arkin, Michelle R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515640/
https://www.ncbi.nlm.nih.gov/pubmed/37676236
http://dx.doi.org/10.1021/jacs.3c05161

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