Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma

Glioblastoma (GBM) is a deadly brain tumor, and the kinesin motor KIF11 is an attractive therapeutic target because of its dual roles in proliferation and invasion. The clinical utility of KIF11 inhibitors has been limited by drug resistance, which has mainly been studied in animal models. We used m...

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Detalles Bibliográficos
Autores principales: Cheng, Yim Ling, Banu, Matei A., Zhao, Wenting, Rosenfeld, Steven S., Canoll, Peter, Sims, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515771/
https://www.ncbi.nlm.nih.gov/pubmed/37745469
http://dx.doi.org/10.1101/2023.09.09.557001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515771/
https://www.ncbi.nlm.nih.gov/pubmed/37745469
http://dx.doi.org/10.1101/2023.09.09.557001

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