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Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma
Glioblastoma (GBM) is a deadly brain tumor, and the kinesin motor KIF11 is an attractive therapeutic target because of its dual roles in proliferation and invasion. The clinical utility of KIF11 inhibitors has been limited by drug resistance, which has mainly been studied in animal models. We used m...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515771/ https://www.ncbi.nlm.nih.gov/pubmed/37745469 http://dx.doi.org/10.1101/2023.09.09.557001 |