A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasis

The contribution of epistasis (interactions among genes or genetic variants) to human complex trait variation remains poorly understood. Methods that aim to explicitly identify pairs of genetic variants, usually single nucleotide polymorphisms (SNPs), associated with a trait suffer from low power du...

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Detalles Bibliográficos
Autores principales: Fu, Boyang, Pazokitoroudi, Ali, Xue, Albert, Anand, Aakarsh, Anand, Prateek, Zaitlen, Noah, Sankararaman, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515811/
https://www.ncbi.nlm.nih.gov/pubmed/37745394
http://dx.doi.org/10.1101/2023.09.10.557084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515811/
https://www.ncbi.nlm.nih.gov/pubmed/37745394
http://dx.doi.org/10.1101/2023.09.10.557084

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