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A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasis
The contribution of epistasis (interactions among genes or genetic variants) to human complex trait variation remains poorly understood. Methods that aim to explicitly identify pairs of genetic variants, usually single nucleotide polymorphisms (SNPs), associated with a trait suffer from low power du...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515811/ https://www.ncbi.nlm.nih.gov/pubmed/37745394 http://dx.doi.org/10.1101/2023.09.10.557084 |