Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency

Beta-Propeller Protein-Associated Neurodegeneration (BPAN) is one of the commonest forms of Neurodegeneration with Brain Iron Accumulation, caused by mutations in the gene encoding the autophagy-related protein, WDR45. The mechanisms linking autophagy, iron overload and neurodegeneration in BPAN are...

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Detalles Bibliográficos
Autores principales: Papandreou, Apostolos, Singh, Nivedita, Gianfrancesco, Lorita, Budinger, Dimitri, Barwick, Katy, Agrotis, Alexander, Luft, Christin, Shao, Ying, Lenaerts, An-Sofie, Gregory, Allison, Jeong, Suh Young, Hogarth, Penelope, Hayflick, Susan, Barral, Serena, Kriston-Vizi, Janos, Gissen, Paul, Kurian, Manju A, Ketteler, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515824/
https://www.ncbi.nlm.nih.gov/pubmed/37745522
http://dx.doi.org/10.1101/2023.09.13.556416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515824/
https://www.ncbi.nlm.nih.gov/pubmed/37745522
http://dx.doi.org/10.1101/2023.09.13.556416

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