Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2

Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersion measurements. These can be described by a global exchange b...

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Detalles Bibliográficos
Autores principales: Anderson, Jake W., Vaisar, David, Jones, David N., Pegram, Laurel M., Vigers, Guy P., Chen, Huifen, Moffat, John G., Ahn, Natalie G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515847/
https://www.ncbi.nlm.nih.gov/pubmed/37745518
http://dx.doi.org/10.1101/2023.09.12.557258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515847/
https://www.ncbi.nlm.nih.gov/pubmed/37745518
http://dx.doi.org/10.1101/2023.09.12.557258

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