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Distinct 3D contacts and phenotypic consequences of adjacent non-coding loci in the epigenetically quiescent regions
Non-coding regions of the human genome are important for functional regulations, but their mechanisms remain elusive. We used machine learning to guide a CRISPR screening on hubs (i.e. non-coding loci forming many 3D contacts) and significantly increased the discovery rate of hubs essential for cell...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515877/ https://www.ncbi.nlm.nih.gov/pubmed/37745584 http://dx.doi.org/10.1101/2023.09.11.557110 |