Sequentially activated death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling

The Yersinia virulence factor YopJ potently inhibits immune signaling in macrophages by blocking activation of the signaling kinases TAK1 and IKK. In response, macrophages trigger a backup pathway of host defense that mediates cell death via the apoptotic enzyme caspase-8 and pyroptotic enzyme caspa...

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Detalles Bibliográficos
Autores principales: Wertman, Ronit Schwartz, Go, Christina K., Saller, Benedikt S., Groß, Olaf, Scott, Phillip, Brodsky, Igor E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515920/
https://www.ncbi.nlm.nih.gov/pubmed/37745613
http://dx.doi.org/10.1101/2023.09.14.557714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515920/
https://www.ncbi.nlm.nih.gov/pubmed/37745613
http://dx.doi.org/10.1101/2023.09.14.557714

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