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Sequentially activated death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling
The Yersinia virulence factor YopJ potently inhibits immune signaling in macrophages by blocking activation of the signaling kinases TAK1 and IKK. In response, macrophages trigger a backup pathway of host defense that mediates cell death via the apoptotic enzyme caspase-8 and pyroptotic enzyme caspa...
Autores principales: | Wertman, Ronit Schwartz, Go, Christina K., Saller, Benedikt S., Groß, Olaf, Scott, Phillip, Brodsky, Igor E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515920/ https://www.ncbi.nlm.nih.gov/pubmed/37745613 http://dx.doi.org/10.1101/2023.09.14.557714 |
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