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Determinants of DDX3X sensitivity uncovered using a helicase activity in translation reporter

DDX3X regulates the translation of a subset of human transcripts containing complex 5′ untranslated regions (5′ UTRs). In this study we developed the helicase activity reporter for translation (HART) which uses DDX3X-sensitive 5′ UTRs to measure DDX3X mediated translational activity in cells. To dis...

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Detalles Bibliográficos
Autores principales: Wilkins, Kevin C., Schroeder, Till, Gu, Sohyun, Revalde, Jezrael L., Floor, Stephen N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515938/
https://www.ncbi.nlm.nih.gov/pubmed/37745530
http://dx.doi.org/10.1101/2023.09.14.557805