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EquiPNAS: improved protein-nucleic acid binding site prediction using protein-language-model-informed equivariant deep graph neural networks

Protein language models (pLMs) trained on a large corpus of protein sequences have shown unprecedented scalability and broad generalizability in a wide range of predictive modeling tasks, but their power has not yet been harnessed for predicting protein-nucleic acid binding sites, critical for chara...

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Detalles Bibliográficos
Autores principales: Roche, Rahmatullah, Moussad, Bernard, Shuvo, Md Hossain, Tarafder, Sumit, Bhattacharya, Debswapna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515942/
https://www.ncbi.nlm.nih.gov/pubmed/37745556
http://dx.doi.org/10.1101/2023.09.14.557719