Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies

HIV-1 envelope glycoproteins (Envs) mediate viral entry and are the sole target of neutralizing antibodies. Envs of most primary HIV-1 strains exist in a closed conformation and occasionally sample more open Env states. Thus, current knowledge guides immunogen design to mimic the closed Env conforma...

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Detalles Bibliográficos
Autores principales: Ratnapriya, Sneha, Pothula, Karunakar Reddy, Dam, Kim-Marie A., Parthasarathy, Durgadevi, Benet, Héctor Cervera, Parsons, Ruth, Huang, Xiao, Sammour, Salam, Janowska, Katarzyna, Harris, Miranda, Ahmed, Shamim, Sacco, Samuel, Sodroski, Joseph, Bridges, Michael D., Hubbell, Wayne L., Acharya, Priyamvada, Herschhorn, Alon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515946/
https://www.ncbi.nlm.nih.gov/pubmed/37745449
http://dx.doi.org/10.1101/2023.09.13.557082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515946/
https://www.ncbi.nlm.nih.gov/pubmed/37745449
http://dx.doi.org/10.1101/2023.09.13.557082

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