Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor in adults. Despite extensive research and clinical trials, median survival post-treatment remains at 15 months. Thus, all opportunities to optimize current treatments and improve patient outcomes should be considered. A recent ret...

Descripción completa

Detalles Bibliográficos
Autores principales: Gonzalez-Aponte, Maria F., Damato, Anna R., Trebucq, Laura Lucía, Simon, Tatiana, Cárdenas-García, Sandra P., Cho, Kevin, Patti, Gary J., Golombek, Diego A., Chiesa, Juan José, Herzog, Erik D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515960/
https://www.ncbi.nlm.nih.gov/pubmed/37745358
http://dx.doi.org/10.1101/2023.09.13.557630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515960/
https://www.ncbi.nlm.nih.gov/pubmed/37745358
http://dx.doi.org/10.1101/2023.09.13.557630

Ejemplares similares