Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation

Amino acid (AA) uptake is essential for T cell metabolism and function, but how tissue sites and inflammation affect CD4(+) T cell subset requirements for specific AA remains uncertain. Here we tested CD4(+) T cell AA demands with in vitro and multiple in vivo CRISPR screens and identify subset- and...

Descripción completa

Detalles Bibliográficos
Autores principales: Sugiura, Ayaka, Beier, Katherine L., Chi, Channing, Heintzman, Darren R., Ye, Xiang, Wolf, Melissa M., Patterson, Andrew R., Cephus, Jacqueline-Yvonne, Hong, Hanna S., Lyssiotis, Costas A., Newcomb, Dawn C., Rathmell, Jeffrey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515961/
https://www.ncbi.nlm.nih.gov/pubmed/37745344
http://dx.doi.org/10.1101/2023.09.13.557496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515961/
https://www.ncbi.nlm.nih.gov/pubmed/37745344
http://dx.doi.org/10.1101/2023.09.13.557496

Ejemplares similares