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Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation

Amino acid (AA) uptake is essential for T cell metabolism and function, but how tissue sites and inflammation affect CD4(+) T cell subset requirements for specific AA remains uncertain. Here we tested CD4(+) T cell AA demands with in vitro and multiple in vivo CRISPR screens and identify subset- and...

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Detalles Bibliográficos
Autores principales:	Sugiura, Ayaka, Beier, Katherine L., Chi, Channing, Heintzman, Darren R., Ye, Xiang, Wolf, Melissa M., Patterson, Andrew R., Cephus, Jacqueline-Yvonne, Hong, Hanna S., Lyssiotis, Costas A., Newcomb, Dawn C., Rathmell, Jeffrey C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515961/ https://www.ncbi.nlm.nih.gov/pubmed/37745344 http://dx.doi.org/10.1101/2023.09.13.557496

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