Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease

The effects of genetic variation on complex traits act mainly through changes in gene regulation. Although many genetic variants have been linked to target genes in cis, the trans-regulatory cascade mediating their effects remains largely uncharacterized. Mapping trans-regulators based on natural ge...

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Detalles Bibliográficos
Autores principales: Weinstock, Joshua S., Arce, Maya M., Freimer, Jacob W., Ota, Mineto, Marson, Alexander, Battle, Alexis, Pritchard, Jonathan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516010/
https://www.ncbi.nlm.nih.gov/pubmed/37745614
http://dx.doi.org/10.1101/2023.09.17.557749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516010/
https://www.ncbi.nlm.nih.gov/pubmed/37745614
http://dx.doi.org/10.1101/2023.09.17.557749

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