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Surprising Features of Nuclear Receptor Interaction Networks Revealed by Live Cell Single Molecule Imaging

Type 2 Nuclear Receptors (T2NRs) require heterodimerization with a common partner, the Retinoid X Receptor (RXR), to bind cognate DNA recognition sites in chromatin. Based on previous biochemical and over-expression studies, binding of T2NRs to chromatin is proposed to be regulated by competition fo...

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Detalles Bibliográficos
Autores principales: Dahal, Liza, Graham, Thomas GW, Dailey, Gina M, Heckert, Alec, Tjian, Robert, Darzacq, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516011/
https://www.ncbi.nlm.nih.gov/pubmed/37745337
http://dx.doi.org/10.1101/2023.09.16.558083