Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high mortality and limited efficacious therapeutic options. PDAC cells undergo metabolic alterations to survive within a nutrient-depleted tumor microenvironment. One critical metabolic shift in PDAC cells occurs through altered is...

Descripción completa

Detalles Bibliográficos
Autores principales: Ensink, Elliot, Jordan, Tessa, Medeiros, Hyllana C D, Thurston, Galloway, Pardal, Anmol, Yu, Lei, Lunt, Sophia Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516027/
https://www.ncbi.nlm.nih.gov/pubmed/37745559
http://dx.doi.org/10.1101/2023.09.15.557984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516027/
https://www.ncbi.nlm.nih.gov/pubmed/37745559
http://dx.doi.org/10.1101/2023.09.15.557984

Ejemplares similares