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Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high mortality and limited efficacious therapeutic options. PDAC cells undergo metabolic alterations to survive within a nutrient-depleted tumor microenvironment. One critical metabolic shift in PDAC cells occurs through altered is...

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Detalles Bibliográficos
Autores principales:	Ensink, Elliot, Jordan, Tessa, Medeiros, Hyllana C D, Thurston, Galloway, Pardal, Anmol, Yu, Lei, Lunt, Sophia Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516027/ https://www.ncbi.nlm.nih.gov/pubmed/37745559 http://dx.doi.org/10.1101/2023.09.15.557984

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