Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells

Interferon (IFN)-α is the earliest cytokine signature observed in individuals at risk for type 1 diabetes (T1D), but its effect on the repertoire of HLA Class I (HLA-I)-bound peptides presented by pancreatic β-cells is unknown. Using immunopeptidomics, we characterized the peptide/HLA-I presentation...

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Detalles Bibliográficos
Autores principales: Carré, Alexia, Zhou, Zhicheng, Perez-Hernandez, Javier, Samassa, Fatoumata, Lekka, Christiana, Manganaro, Anthony, Oshima, Masaya, Liao, Hanqing, Parker, Robert, Nicastri, Annalisa, Brandao, Barbara, Colli, Maikel L., Eizirik, Decio L., Göransson, Marcus, Morales, Orlando Burgos, Anderson, Amanda, Landry, Laurie, Kobaisi, Farah, Scharfmann, Raphael, Marselli, Lorella, Marchetti, Piero, You, Sylvaine, Nakayama, Maki, Hadrup, Sine R., Kent, Sally C., Richardson, Sarah J., Ternette, Nicola, Mallone, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516036/
https://www.ncbi.nlm.nih.gov/pubmed/37745505
http://dx.doi.org/10.1101/2023.09.15.557918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516036/
https://www.ncbi.nlm.nih.gov/pubmed/37745505
http://dx.doi.org/10.1101/2023.09.15.557918

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