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Nucleic Acid Mediated Activation of a Short Prokaryotic Argonaute Immune System
The continual pressure of invading DNA has led bacteria to develop numerous immune systems, including a short prokaryotic Argonaute (pAgo) TIR-APAZ system (SPARTA) that is activated by invading DNA to unleash its TIR domain for NAD(P)(+) hydrolysis. To gain a molecular understanding of this activati...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516056/ https://www.ncbi.nlm.nih.gov/pubmed/37745538 http://dx.doi.org/10.1101/2023.09.17.558117 |