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Nucleic Acid Mediated Activation of a Short Prokaryotic Argonaute Immune System

The continual pressure of invading DNA has led bacteria to develop numerous immune systems, including a short prokaryotic Argonaute (pAgo) TIR-APAZ system (SPARTA) that is activated by invading DNA to unleash its TIR domain for NAD(P)(+) hydrolysis. To gain a molecular understanding of this activati...

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Detalles Bibliográficos
Autores principales: Kottur, Jithesh, Malik, Radhika, Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516056/
https://www.ncbi.nlm.nih.gov/pubmed/37745538
http://dx.doi.org/10.1101/2023.09.17.558117