Sensing Cytosolic DNA Lowers Blood Pressure by Direct cGAMP-Dependent PKGI Activation

BACKGROUND: The major cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) has emerged as a key mediator of inflammation that underlies cardiovascular disease. On interaction with double-stranded DNA, cGAS generates the second messenger 2′,3′-cyclic GMP-AMP (cGAMP) that directly binds to and activate...

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Detalles Bibliográficos
Autores principales: Su, Jie, Coleman, Pierre, Ntorla, Angeliki, Anderson, Rhys, Shattock, Michael J., Burgoyne, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516174/
https://www.ncbi.nlm.nih.gov/pubmed/37548012
http://dx.doi.org/10.1161/CIRCULATIONAHA.123.065547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516174/
https://www.ncbi.nlm.nih.gov/pubmed/37548012
http://dx.doi.org/10.1161/CIRCULATIONAHA.123.065547

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