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Sensing Cytosolic DNA Lowers Blood Pressure by Direct cGAMP-Dependent PKGI Activation

BACKGROUND: The major cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) has emerged as a key mediator of inflammation that underlies cardiovascular disease. On interaction with double-stranded DNA, cGAS generates the second messenger 2′,3′-cyclic GMP-AMP (cGAMP) that directly binds to and activate...

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Detalles Bibliográficos
Autores principales:	Su, Jie, Coleman, Pierre, Ntorla, Angeliki, Anderson, Rhys, Shattock, Michael J., Burgoyne, Joseph R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516174/ https://www.ncbi.nlm.nih.gov/pubmed/37548012 http://dx.doi.org/10.1161/CIRCULATIONAHA.123.065547

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