Suppression of hnRNP A1 binding to HK1 RNA leads to glycolytic dysfunction in Alzheimer’s disease models

OBJECTIVE: To investigate the mechanism of RNA-binding protein hnRNP A1 in mouse hippocampal neurons (HT22) on glycolysis. METHODS: RIP and CLIP-qPCR were performed by HT22 in vitro to observe the mechanism of hnRNP A1 regulating the expression of key proteins in glycolysis. The RNA binding domain o...

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Detalles Bibliográficos
Autores principales: Ji, Xin-Hao, Liu, Ting-Ting, Wei, Ai-Hong, Lei, Hui-Ping, Chen, Yue, Wu, Ling-Nan, Liu, Ju, Zhang, Ying, Yan, Fei, Chen, Mei-Xiang, Jin, Hai, Shi, Jing-Shan, Zhou, Shao-Yu, Jin, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516183/
https://www.ncbi.nlm.nih.gov/pubmed/37744386
http://dx.doi.org/10.3389/fnagi.2023.1218267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516183/
https://www.ncbi.nlm.nih.gov/pubmed/37744386
http://dx.doi.org/10.3389/fnagi.2023.1218267

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