Systematic investigation of the homology sequences around the human fusion gene breakpoints in pan-cancer – bioinformatics study for a potential link to MMEJ

Microhomology-mediated end joining (MMEJ), an error-prone DNA damage repair mechanism, frequently leads to chromosomal rearrangements due to its ability to engage in promiscuous end joining of genomic instability and also leads to increasing mutational load at the sequences flanking the breakpoints...

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Detalles Bibliográficos
Autores principales: Kim, Pora, Kumar, Himansu, Yang, Chengyuan, Luo, Ruihan, Liu, Jiajia, Zhou, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Problem Solving Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516359/
https://www.ncbi.nlm.nih.gov/pubmed/37635381
http://dx.doi.org/10.1093/bib/bbad314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516359/
https://www.ncbi.nlm.nih.gov/pubmed/37635381
http://dx.doi.org/10.1093/bib/bbad314

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