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Age-dependent acquisition of pathogenicity by SARS-CoV-2 Omicron BA.5

Pathology studies of SARS-CoV-2 Omicron variants of concern (VOC) are challenged by the lack of pathogenic animal models. While Omicron BA.1 and BA.2 replicate in K18-hACE2 transgenic mice, they cause minimal to negligible morbidity and mortality, and less is known about more recent Omicron VOC. Her...

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Detalles Bibliográficos
Autores principales: Imbiakha, Brian, Ezzatpour, Shahrzad, Buchholz, David W., Sahler, Julie, Ye, Chengjin, Olarte-Castillo, Ximena A., Zou, Anna, Kwas, Cole, O’Hare, Katelyn, Choi, Annette, Adeleke, Richard Ayomide, Khomandiak, Solomiia, Goodman, Laura, Jager, Mason C., Whittaker, Gary R., Martinez-Sobrido, Luis, August, Avery, Aguilar, Hector C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516498/
https://www.ncbi.nlm.nih.gov/pubmed/37738347
http://dx.doi.org/10.1126/sciadv.adj1736