Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion

Prolonged cytopenias after chimeric antigen receptor (CAR) T cell therapy are a significant clinical problem and the underlying pathophysiology remains poorly understood. Here, we investigated how (CAR) T cell expansion dynamics and serum proteomics affect neutrophil recovery phenotypes after CD19-d...

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Detalles Bibliográficos
Autores principales: Rejeski, Kai, Perez, Ariel, Iacoboni, Gloria, Blumenberg, Viktoria, Bücklein, Veit L., Völkl, Simon, Penack, Olaf, Albanyan, Omar, Stock, Sophia, Müller, Fabian, Karschnia, Philipp, Petrera, Agnese, Reid, Kayla, Faramand, Rawan, Davila, Marco L., Modi, Karnav, Dean, Erin A., Bachmeier, Christina, von Bergwelt-Baildon, Michael, Locke, Frederick L, Bethge, Wolfgang, Bullinger, Lars, Mackensen, Andreas, Barba, Pere, Jain, Michael D., Subklewe, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516499/
https://www.ncbi.nlm.nih.gov/pubmed/37738350
http://dx.doi.org/10.1126/sciadv.adg3919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516499/
https://www.ncbi.nlm.nih.gov/pubmed/37738350
http://dx.doi.org/10.1126/sciadv.adg3919

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