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Temporal landscape of mitochondrial proteostasis governed by the UPR(mt)
Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPR(mt)) and PINK1/Parkin mitophagy. However, beyond the up-regulation of chaperones and proteases, we have a limited understanding of how the UPR(mt) remodels and restor...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516501/ https://www.ncbi.nlm.nih.gov/pubmed/37738349 http://dx.doi.org/10.1126/sciadv.adh8228 |