Cyclophosphamide augments the efficacy of in situ vaccination in a mouse melanoma model

INTRODUCTION: We have previously shown that an intratumoral (IT) injection of the hu14.18-IL2 immunocytokine (IC), an anti-GD2 antibody linked to interleukin 2, can serve as an in situ vaccine and synergize with local radiotherapy (RT) to induce T cell-mediated antitumor effects. We hypothesized tha...

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Detalles Bibliográficos
Autores principales: Tsarovsky, Noah, Felder, Mildred, Heck, Mackenzie, Slowinski, Jacob, Rasmussen, Kayla, VandenHeuvel, Sabrina, Zaborek, Jen, Morris, Zachary S., Erbe, Amy K., Sondel, Paul M., Rakhmilevich, Alexander L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516537/
https://www.ncbi.nlm.nih.gov/pubmed/37746303
http://dx.doi.org/10.3389/fonc.2023.1200436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516537/
https://www.ncbi.nlm.nih.gov/pubmed/37746303
http://dx.doi.org/10.3389/fonc.2023.1200436

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