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Cyclophosphamide augments the efficacy of in situ vaccination in a mouse melanoma model
INTRODUCTION: We have previously shown that an intratumoral (IT) injection of the hu14.18-IL2 immunocytokine (IC), an anti-GD2 antibody linked to interleukin 2, can serve as an in situ vaccine and synergize with local radiotherapy (RT) to induce T cell-mediated antitumor effects. We hypothesized tha...
Autores principales: | Tsarovsky, Noah, Felder, Mildred, Heck, Mackenzie, Slowinski, Jacob, Rasmussen, Kayla, VandenHeuvel, Sabrina, Zaborek, Jen, Morris, Zachary S., Erbe, Amy K., Sondel, Paul M., Rakhmilevich, Alexander L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516537/ https://www.ncbi.nlm.nih.gov/pubmed/37746303 http://dx.doi.org/10.3389/fonc.2023.1200436 |
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