Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism

RIG-I (retinoic acid inducible gene-I) can sense subtle differences between endogenous and viral RNA in the cytoplasm, triggering an anti-viral immune response through induction of type I interferons (IFN) and other inflammatory mediators. Multiple crystal and cryo-EM structures of RIG-I suggested a...

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Detalles Bibliográficos
Autores principales: Sikorska, Justyna, Hou, Yan, Chiurazzi, Paul, Siu, Tony, Baltus, Gretchen A, Sheth, Payal, McLaren, David G, Truong, Quang, Parish, Craig A, Wyss, Daniel F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516622/
https://www.ncbi.nlm.nih.gov/pubmed/37486777
http://dx.doi.org/10.1093/nar/gkad606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516622/
https://www.ncbi.nlm.nih.gov/pubmed/37486777
http://dx.doi.org/10.1093/nar/gkad606

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