Pot1b (−/−) tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongation

Malignant cancers must activate telomere maintenance mechanisms to achieve replicative immortality. Mutations in the human Protection of Telomeres 1 (POT1) gene are frequently detected in cancers with abnormally long telomeres, suggesting that the loss of POT1 function disrupts the regulation of tel...

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Detalles Bibliográficos
Autores principales: Takasugi, Taylor, Gu, Peili, Liang, Fengshan, Staco, Isabelle, Chang, Sandy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516629/
https://www.ncbi.nlm.nih.gov/pubmed/37560909
http://dx.doi.org/10.1093/nar/gkad648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516629/
https://www.ncbi.nlm.nih.gov/pubmed/37560909
http://dx.doi.org/10.1093/nar/gkad648

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