Cargando…
Pot1b (−/−) tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongation
Malignant cancers must activate telomere maintenance mechanisms to achieve replicative immortality. Mutations in the human Protection of Telomeres 1 (POT1) gene are frequently detected in cancers with abnormally long telomeres, suggesting that the loss of POT1 function disrupts the regulation of tel...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516629/ https://www.ncbi.nlm.nih.gov/pubmed/37560909 http://dx.doi.org/10.1093/nar/gkad648 |