Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells

Dot1l is a histone methyltransferase without a SET domain and is responsible for H3K79 methylation, which marks active transcription. In contradiction, Dot1l also participates in silencing gene expression. The target regions and mechanism of Dot1l in repressing transcription remain enigmatic. Here,...

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Detalles Bibliográficos
Autores principales: Zhao, Xin, Li, Xiaomin, Sun, Haiyang, Zhao, Xuan, Gao, Tingting, Shi, Panpan, Chen, Fuquan, Liu, Lin, Lu, Xinyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516645/
https://www.ncbi.nlm.nih.gov/pubmed/37522386
http://dx.doi.org/10.1093/nar/gkad640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516645/
https://www.ncbi.nlm.nih.gov/pubmed/37522386
http://dx.doi.org/10.1093/nar/gkad640

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