Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD(+) levels

Though the effect of the recently identified mitochondrial NAD(+) transporter SLC25A51 on glucose metabolism has been described, its contribution to other NAD(+)-dependent processes throughout the cell such as ADP-ribosylation remains elusive. Here, we report that absence of SLC25A51 leads to increa...

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Detalles Bibliográficos
Autores principales: Güldenpfennig, Anka, Hopp, Ann-Katrin, Muskalla, Lukas, Manetsch, Patrick, Raith, Fabio, Hellweg, Lars, Dördelmann, Cyril, Leslie Pedrioli, Deena M, Johnsson, Kai, Superti-Furga, Giulio, Hottiger, Michael O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516648/
https://www.ncbi.nlm.nih.gov/pubmed/37587695
http://dx.doi.org/10.1093/nar/gkad659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516648/
https://www.ncbi.nlm.nih.gov/pubmed/37587695
http://dx.doi.org/10.1093/nar/gkad659

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