The induction of p53 correlates with defects in the production, but not the levels, of the small ribosomal subunit and stalled large ribosomal subunit biogenesis

Ribosome biogenesis is one of the biggest consumers of cellular energy. More than 20 genetic diseases (ribosomopathies) and multiple cancers arise from defects in the production of the 40S (SSU) and 60S (LSU) ribosomal subunits. Defects in the production of either the SSU or LSU result in p53 induct...

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Detalles Bibliográficos
Autores principales: Eastham, Matthew John, Pelava, Andria, Wells, Graeme Raymond, Lee, Justine Katherine, Lawrence, Isabella Rachel, Stewart, Joshua, Deichner, Maria, Hertle, Regina, Watkins, Nicholas James, Schneider, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516649/
https://www.ncbi.nlm.nih.gov/pubmed/37526268
http://dx.doi.org/10.1093/nar/gkad637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516649/
https://www.ncbi.nlm.nih.gov/pubmed/37526268
http://dx.doi.org/10.1093/nar/gkad637

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