A mutation-sensitive, multiplexed and amplification-free detection of nucleic acids by stretching single-molecule tandem hairpin probes

The detection of nucleic acid sequences in parallel with the discrimination of single nucleotide variations (SNVs) is critical for research and clinical applications. A few limitations make the detection technically challenging, such as too small variation in probe-hybridization energy caused by SNV...

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Detalles Bibliográficos
Autores principales: Yang, Ya-Jun, Fu, Hang, Li, Xiao-Lu, Yang, Hong-Yu, Zhou, Er-Chi, Xie, Cheng-Yu, Wu, Shu-Wen, He, Fan, Zhang, Yan, Zhang, Xing-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516651/
https://www.ncbi.nlm.nih.gov/pubmed/37562941
http://dx.doi.org/10.1093/nar/gkad601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516651/
https://www.ncbi.nlm.nih.gov/pubmed/37562941
http://dx.doi.org/10.1093/nar/gkad601

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