Observing inhibition of the SARS-CoV-2 helicase at single-nucleotide resolution

The genome of SARS-CoV-2 encodes for a helicase (nsp13) that is essential for viral replication and highly conserved across related viruses, making it an attractive antiviral target. Here we use nanopore tweezers, a high-resolution single-molecule technique, to gain detailed insight into how nsp13 t...

Descripción completa

Detalles Bibliográficos
Autores principales: Marx, Sinduja K, Mickolajczyk, Keith J, Craig, Jonathan M, Thomas, Christopher A, Pfeffer, Akira M, Abell, Sarah J, Carrasco, Jessica D, Franzi, Michaela C, Huang, Jesse R, Kim, Hwanhee C, Brinkerhoff, Henry, Kapoor, Tarun M, Gundlach, Jens H, Laszlo, Andrew H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516658/
https://www.ncbi.nlm.nih.gov/pubmed/37560916
http://dx.doi.org/10.1093/nar/gkad660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516658/
https://www.ncbi.nlm.nih.gov/pubmed/37560916
http://dx.doi.org/10.1093/nar/gkad660

Ejemplares similares