Evaluation of the determinants for improved pluripotency induction and maintenance by engineered SOX17

An engineered SOX17 variant with point mutations within its DNA binding domain termed SOX17FNV is a more potent pluripotency inducer than SOX2, yet the underlying mechanism remains unclear. Although wild-type SOX17 was incapable of inducing pluripotency, SOX17FNV outperformed SOX2 in mouse and human...

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Detalles Bibliográficos
Autores principales: Hu, Haoqing, Ho, Derek Hoi Hang, Tan, Daisylyn Senna, MacCarthy, Caitlin M, Yu, Cheng-han, Weng, Mingxi, Schöler, Hans Robert, Jauch, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516664/
https://www.ncbi.nlm.nih.gov/pubmed/37607832
http://dx.doi.org/10.1093/nar/gkad597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516664/
https://www.ncbi.nlm.nih.gov/pubmed/37607832
http://dx.doi.org/10.1093/nar/gkad597

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