Cargando…

Evaluation of the determinants for improved pluripotency induction and maintenance by engineered SOX17

An engineered SOX17 variant with point mutations within its DNA binding domain termed SOX17FNV is a more potent pluripotency inducer than SOX2, yet the underlying mechanism remains unclear. Although wild-type SOX17 was incapable of inducing pluripotency, SOX17FNV outperformed SOX2 in mouse and human...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Haoqing, Ho, Derek Hoi Hang, Tan, Daisylyn Senna, MacCarthy, Caitlin M, Yu, Cheng-han, Weng, Mingxi, Schöler, Hans Robert, Jauch, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516664/ https://www.ncbi.nlm.nih.gov/pubmed/37607832 http://dx.doi.org/10.1093/nar/gkad597

Ejemplares similares

OCT4 interprets and enhances nucleosome flexibility
por: MacCarthy, Caitlin M, et al.
Publicado: (2022)

The homeodomain of Oct4 is a dimeric binder of methylated CpG elements
por: Tan, Daisylyn Senna, et al.
Publicado: (2023)

DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors
por: Narasimhan, Kamesh, et al.
Publicado: (2015)

Foxm1 transcription factor is required for maintenance of pluripotency of P19 embryonal carcinoma cells
por: Xie, Zhongqiu, et al.
Publicado: (2010)

The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis
por: Liu, Chia-Feng, et al.
Publicado: (2015)

An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming
por: Weng, Mingxi, et al.
Publicado: (2023)

The transcription factor Sox5 modulates Sox10 function during melanocyte development
por: Stolt, C. Claus, et al.
Publicado: (2008)

A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells
por: Cantu', Claudio, et al.
Publicado: (2011)

SOX9 reprograms endothelial cells by altering the chromatin landscape
por: Fuglerud, Bettina M, et al.
Publicado: (2022)

BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation
por: Marathe, Himangi G., et al.
Publicado: (2017)

Emx2 is a dose-dependent negative regulator of Sox2 telencephalic enhancers
por: Mariani, J., et al.
Publicado: (2012)

Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve
por: Srinivasan, Rajini, et al.
Publicado: (2012)

Myrf guides target gene selection of transcription factor Sox10 during oligodendroglial development
por: Aprato, Jessica, et al.
Publicado: (2020)

Distinct transcriptional regulatory modules underlie STAT3’s cell type-independent and cell type-specific functions
por: Hutchins, Andrew Paul, et al.
Publicado: (2013)

The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template
por: Coustry, Françoise, et al.
Publicado: (2010)

Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer
por: Küspert, Melanie, et al.
Publicado: (2011)

Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells
por: Shi, Zhongcheng, et al.
Publicado: (2015)

Transcription factor Sox10 orchestrates activity of a neural crest-specific enhancer in the vicinity of its gene
por: Wahlbuhl, Mandy, et al.
Publicado: (2012)

The SOX9 upstream region prone to chromosomal aberrations causing campomelic dysplasia contains multiple cartilage enhancers
por: Yao, Baojin, et al.
Publicado: (2015)

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity
por: McCann, Alex J, et al.
Publicado: (2021)

DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1
por: Wang, Xuecong, et al.
Publicado: (2018)

In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures
por: Rahmoun, Massilva, et al.
Publicado: (2017)

KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF
por: Bernhardt, Celine, et al.
Publicado: (2022)

A far-upstream (−70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration
por: Mead, Timothy J., et al.
Publicado: (2013)

ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells
por: Roper, Stephen J., et al.
Publicado: (2014)

Transcriptional network dynamics during the progression of pluripotency revealed by integrative statistical learning
por: Kim, Hani Jieun, et al.
Publicado: (2020)

A novel requirement for DROSHA in maintenance of mammalian CG methylation
por: Stathopoulou, Athanasia, et al.
Publicado: (2017)

Expression of endogenous retroviruses is negatively regulated by the pluripotency marker Rex1/Zfp42
por: Guallar, D., et al.
Publicado: (2012)

Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition
por: Quan, Yujun, et al.
Publicado: (2022)

Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components
por: Ugur, Enes, et al.
Publicado: (2023)

The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance
por: Peng, Jing, et al.
Publicado: (2012)

HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells
por: Kidder, Benjamin L., et al.
Publicado: (2012)

RAR/RXR binding dynamics distinguish pluripotency from differentiation associated cis-regulatory elements
por: Chatagnon, Amandine, et al.
Publicado: (2015)

GCNA is a histone binding protein required for spermatogonial stem cell maintenance
por: Ribeiro, Jonathan, et al.
Publicado: (2023)

TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues
por: Neri, Francesco, et al.
Publicado: (2015)

A hyperdynamic H3.3 nucleosome marks promoter regions in pluripotent embryonic stem cells
por: Schlesinger, Sharon, et al.
Publicado: (2017)

Chromatin Assembly Factor 1 (CAF-1) facilitates the establishment of facultative heterochromatin during pluripotency exit
por: Cheng, Liang, et al.
Publicado: (2019)

HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells
por: Zaidan, Nur Zafirah, et al.
Publicado: (2020)

TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells
por: Jin, Chunlei, et al.
Publicado: (2014)

Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC
por: Tata, Purushothama R., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_12r6o38tcu4rjofchqpaarnd4v