Telomerase RNA-based aptamers restore defective myelopoiesis in congenital neutropenic syndromes

Telomerase RNA (TERC) has a noncanonical function in myelopoiesis binding to a consensus DNA binding sequence and attracting RNA polymerase II (RNA Pol II), thus facilitating myeloid gene expression. The CR4/CR5 domain of TERC is known to play this role, since a mutation of this domain found in dysk...

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Detalles Bibliográficos
Autores principales: Martínez-Balsalobre, Elena, García-Castillo, Jesús, García-Moreno, Diana, Naranjo-Sánchez, Elena, Fernández-Lajarín, Miriam, Blasco, María A., Alcaraz-Pérez, Francisca, Mulero, Victoriano, Cayuela, María L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516865/
https://www.ncbi.nlm.nih.gov/pubmed/37737237
http://dx.doi.org/10.1038/s41467-023-41472-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516865/
https://www.ncbi.nlm.nih.gov/pubmed/37737237
http://dx.doi.org/10.1038/s41467-023-41472-7

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