Cargando…

Structural and functional characterization of USP47 reveals a hot spot for inhibitor design

USP47 is widely involved in tumor development, metastasis, and other processes while performing a more regulatory role in inflammatory responses, myocardial infarction, and neuronal development. In this study, we investigate the functional and biochemical properties of USP47, whereby depleting USP47...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shin, Sang Chul, Park, Jinyoung, Kim, Kyung Hee, Yoon, Jung Min, Cho, Jinhong, Ha, Byung Hak, Oh, Yeonji, Choo, Hyunah, Song, Eun Joo, Kim, Eunice EunKyeong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516900/ https://www.ncbi.nlm.nih.gov/pubmed/37740002 http://dx.doi.org/10.1038/s42003-023-05345-5

Ejemplares similares

MicroRNA-101-3p Suppresses Cancer Cell Growth by Inhibiting the USP47-Induced Deubiquitination of RPL11
por: Park, Jinyoung, et al.
Publicado: (2022)

USP47 Promotes Tumorigenesis by Negative Regulation of p53 through Deubiquitinating Ribosomal Protein S2
por: Cho, Jinhong, et al.
Publicado: (2020)

USP35 regulates mitotic progression by modulating the stability of Aurora B
por: Park, Jinyoung, et al.
Publicado: (2018)

The Multifaceted Roles of USP15 in Signal Transduction
por: Das, Tanuza, et al.
Publicado: (2021)

Assay Systems for Profiling Deubiquitinating Activity
por: Cho, Jinhong, et al.
Publicado: (2020)

Deubiquitinating Enzymes: A Critical Regulator of Mitosis
por: Park, Jinyoung, et al.
Publicado: (2019)

USP15 regulates dynamic protein–protein interactions of the spliceosome through deubiquitination of PRP31
por: Das, Tanuza, et al.
Publicado: (2017)

USP15 regulates dynamic protein–protein interactions of the spliceosome through deubiquitination of PRP31
por: Das, Tanuza, et al.
Publicado: (2017)

USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1
por: Das, Tanuza, et al.
Publicado: (2022)

Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3
por: Park, Joon Kyu, et al.
Publicado: (2016)

Proteasome inhibitors attenuated cholesterol-induced cardiac hypertrophy in H9c2 cells
por: Lee, Hyunjung, et al.
Publicado: (2016)

Regulation of Deubiquitinating Enzymes by Post-Translational Modifications
por: Das, Tanuza, et al.
Publicado: (2020)

Molecular dynamics simulation reveals the possible druggable hot-spots of USP7
por: Srivastava, Mitul, et al.
Publicado: (2018)

MiR‐195 and miR‐497 suppress tumorigenesis in lung cancer by inhibiting SMURF2‐induced TGF‐β receptor I ubiquitination
por: Chae, Dong‐Kyu, et al.
Publicado: (2019)

Deubiquitinase USP35 as a novel mitotic regulator via maintenance of Aurora B stability
por: Park, Jinyoung, et al.
Publicado: (2018)

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation
por: Palazón‐Riquelme, Pablo, et al.
Publicado: (2018)

The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation
por: Song, Soonhwa, et al.
Publicado: (2022)

Analysis of Biological Features Associated with Meiotic Recombination Hot and Cold Spots in Saccharomyces cerevisiae
por: Hansen, Loren, et al.
Publicado: (2011)

HotSpot Wizard: a web server for identification of hot spots in protein engineering
por: Pavelka, Antonin, et al.
Publicado: (2009)

Biodiversity hot spot on a hot spot: novel extremophile diversity in Hawaiian fumaroles
por: Wall, Kate, et al.
Publicado: (2015)

Post-insertion technique to introduce targeting moieties in milk exosomes for targeted drug delivery
por: Jang, Hochung, et al.
Publicado: (2023)

Yellowstone Hot Springs are Organic Chemodiversity Hot Spots
por: Gonsior, Michael, et al.
Publicado: (2018)

Hot spots discussed at Bonn
Publicado: (1979)

DESY: Hot spots in the nucleon?
Publicado: (1990)

Hot spots discussed at Bonn
por: Weiner, Richard M
Publicado: (1979)

Identifying Malaria Hot Spots
por: White, Nicholas J
Publicado: (2017)

Two evolutionarily conserved sequence elements for Peg3/Usp29 transcription
por: Kim, Jeong Do, et al.
Publicado: (2008)

Why is the H(3)(+) hot spot above Jupiter's Great Red Spot so hot?
por: Ray, L. C., et al.
Publicado: (2019)

USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer
por: Pan, Beiqing, et al.
Publicado: (2019)

Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA
por: Ka, Hye In, et al.
Publicado: (2020)

Identifying the Hot Spot Residues of the SARS-CoV-2 Main Protease Using MM-PBSA and Multiple Force Fields
por: Byun, Jinyoung, et al.
Publicado: (2021)

Ubiquitin–proteasome system (UPS) as a target for anticancer treatment
por: Park, Jinyoung, et al.
Publicado: (2020)

HotSprint: database of computational hot spots in protein interfaces
por: Guney, Emre, et al.
Publicado: (2008)

HotPoint: hot spot prediction server for protein interfaces
por: Tuncbag, Nurcan, et al.
Publicado: (2010)

HotRegion: a database of predicted hot spot clusters
por: Cukuroglu, Engin, et al.
Publicado: (2012)

Methodology and software to detect viral integration site hot-spots
por: Presson, Angela P, et al.
Publicado: (2011)

Deubiquitinylase USP47 Promotes RelA Phosphorylation and Survival in Gastric Cancer Cells
por: Naghavi, Lara, et al.
Publicado: (2018)

Anatomy of mouse recombination hot spots
por: Wu, Zhen K., et al.
Publicado: (2010)

Fragments and hot spots in drug discovery
por: Vajda, Sandor, et al.
Publicado: (2015)

Hot spots of unseen fishing vessels
por: Welch, Heather, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s5pmnr7nu1u5llgh45echobe5i