Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex

Biological processes are typically actuated by dynamic multi-subunit molecular complexes. However, interactions between subunits, which govern the functions of these complexes, are hard to measure directly. Here, we develop a general approach combining cryo-EM imaging technology and statistical mode...

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Detalles Bibliográficos
Autores principales: Han, Xu, Zhang, Dongliang, Hong, Lu, Yu, Daqi, Wu, Zhaolong, Yang, Tian, Rust, Michael, Tu, Yuhai, Ouyang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516925/
https://www.ncbi.nlm.nih.gov/pubmed/37737245
http://dx.doi.org/10.1038/s41467-023-41575-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516925/
https://www.ncbi.nlm.nih.gov/pubmed/37737245
http://dx.doi.org/10.1038/s41467-023-41575-1

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