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Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding

Hydroxycarboxylic acid receptors (HCA) are expressed in various tissues and immune cells. HCA2 and its agonist are thus important targets for treating inflammatory and metabolic disorders. Only limited information is available, however, on the active-state binding of HCAs with agonists. Here, we pre...

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Detalles Bibliográficos
Autores principales: Suzuki, Shota, Tanaka, Kotaro, Nishikawa, Kouki, Suzuki, Hiroshi, Oshima, Atsunori, Fujiyoshi, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516952/
https://www.ncbi.nlm.nih.gov/pubmed/37736747
http://dx.doi.org/10.1038/s41467-023-41650-7

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