SL-scan identifies synthetic lethal interactions in cancer using metabolic networks

Exploiting synthetic lethality is a promising strategy for developing targeted cancer therapies. However, identifying clinically significant synthetic lethal (SL) interactions among a large number of gene combinations is a challenging computational task. In this study, we developed the SL-scan pipel...

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Detalles Bibliográficos
Autores principales: Zangene, Ehsan, Marashi, Sayed-Amir, Montazeri, Hesam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516981/
https://www.ncbi.nlm.nih.gov/pubmed/37737478
http://dx.doi.org/10.1038/s41598-023-42992-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516981/
https://www.ncbi.nlm.nih.gov/pubmed/37737478
http://dx.doi.org/10.1038/s41598-023-42992-4

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