YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis

Small cell lung cancer (SCLC) is highly lethal due to its prevalent metastasis. Most SCLCs have inactivating mutations in TP53 and RB1. We find that loss of YAP expression is key for SCLC cells to acquire rapid ameboid migration and high metastatic potential. YAP functions through its target genes C...

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Detalles Bibliográficos
Autores principales: Wu, Zhengming, Su, Junhui, Li, Fu-long, Chen, Tao, Mayner, Jaimie, Engler, Adam, Ma, Shenghong, Li, Qingquan, Guan, Kun-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516997/
https://www.ncbi.nlm.nih.gov/pubmed/37739954
http://dx.doi.org/10.1038/s41467-023-41585-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516997/
https://www.ncbi.nlm.nih.gov/pubmed/37739954
http://dx.doi.org/10.1038/s41467-023-41585-z

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