SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity

CSCs (Cancer stem cells) with distinct metabolic features are considered to cause HCC (hepatocellular carcinoma) initiation, metastasis and therapeutic resistance. Here, we perform a metabolic gene CRISPR/Cas9 knockout library screen in tumorspheres derived from HCC cells and find that deletion of S...

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Detalles Bibliográficos
Autores principales: Wang, Feng, Gao, Yang, Xue, Situ, Zhao, Luyao, Jiang, Huimin, Zhang, Tingting, Li, Yunxuan, Zhao, Chenxi, Wu, Fan, Siqin, Tana, Liu, Ying, Wu, Jie, Yan, Yechao, Yuan, Jian, Jiang, Jian-dong, Li, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517016/
https://www.ncbi.nlm.nih.gov/pubmed/37739936
http://dx.doi.org/10.1038/s41467-023-41593-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517016/
https://www.ncbi.nlm.nih.gov/pubmed/37739936
http://dx.doi.org/10.1038/s41467-023-41593-z

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