Pathway-specific polygenic scores for Alzheimer’s disease are associated with changes in brain structure in younger and older adults

Genome-wide association studies have identified multiple Alzheimer’s disease risk loci with small effect sizes. Polygenic risk scores, which aggregate these variants, are associated with grey matter structural changes. However, genome-wide scores do not allow mechanistic interpretations. The present...

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Detalles Bibliográficos
Autores principales: Harrison, Judith R, Foley, Sonya F, Baker, Emily, Bracher-Smith, Matthew, Holmans, Peter, Stergiakouli, Evie, Linden, David E J, Caseras, Xavier, Jones, Derek K, Escott-Price, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517196/
https://www.ncbi.nlm.nih.gov/pubmed/37744023
http://dx.doi.org/10.1093/braincomms/fcad229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517196/
https://www.ncbi.nlm.nih.gov/pubmed/37744023
http://dx.doi.org/10.1093/braincomms/fcad229

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