A Novel Inactive Isoform with a Restored Reading Frame Is Expressed from the Human Interferon Lambda 4 TT Allele at rs368234815

The TT allele of the dinucleotide variant rs368234815 (TT/ΔG) abolishes the open reading frame (ORF) created by the ancestral ΔG allele of the human interferon lambda 4 (IFNL4) gene, thus preventing the expression of a functional IFN-λ4 protein. While probing the expression of IFN-λ4 in human periph...

Descripción completa

Detalles Bibliográficos
Autores principales: Bharatiya, Seema, Agarwal, Aditya, Chinnaswamy, Sreedhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2023
Materias:
Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517323/
https://www.ncbi.nlm.nih.gov/pubmed/36880961
http://dx.doi.org/10.1089/jir.2022.0199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517323/
https://www.ncbi.nlm.nih.gov/pubmed/36880961
http://dx.doi.org/10.1089/jir.2022.0199

Ejemplares similares